Nafld Fibrosis Score Test. These include FibroTest-ActiTest, a first-line screening assay that u
These include FibroTest-ActiTest, a first-line screening assay that uses two diagnostic scores based on component tests for six biomarkers to assess the liver for nonalcoholic fatty liver disease (NAFLD); nonalcoholic steatohepatitis (NASH)-FibroTest, which evaluates 10 biomarkers to assess liver condition; and direct alcohol biomarker testing Nov 15, 2020 · There are two forms of NAFLD: nonalcoholic fatty liver (NAFL), defined as 5% or greater hepatic steatosis without hepatocellular injury or fibrosis, and nonalcoholic steatohepatitis (NASH Fibrosis-4 (FIB-4) is a clinical marker used to evaluate the degree of liver fibrosis, particularly in patients with chronic liver diseases like hepatitis C and non-alcoholic fatty liver disease (NAFLD). In some patients, this fat accumulation is accompanied by varying degrees of inflammation and fibrosis (nonalcoholic steatohepatitis [NASH]). It’s a win-win for clinicians and patients to avoid liver biopsies if they can get similar information from risk scores. Clinical Question Which patients with nonalcoholic fatty liver disease (NAFLD) have a low likelihood of fibrosis or cirrhosis? Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, affecting at least a quarter of the global adult population. 3 days ago · FibroScan (vibration-controlled transient elastography) is indicated as a second-line test after initial risk stratification with simple fibrosis scores (FIB-4 or NAFLD Fibrosis Score) in patients with suspected NASH who have obesity, diabetes, or metabolic syndrome, specifically when these initial scores fall in the indeterminate range or to Fibrosis-4 (FIB-4) Calculator Share The Fibrosis-4 score helps to estimate the amount of scarring in the liver. . For additional testing options that include the FIB-4 index, consult the Quest online Test Directory. What makes this test different? The NAFLD Fibrosis Score is a validated, noninvasive tool for identifying patients whose MASLD has advanced to liver fibrosis. The FibroMeter NAFLD test is a non-invasive alternative to liver biopsy and serves as a surrogate marker of liver fibrosis specifically in patients with chronic liver disease due to NAFLD. This information can help the healthcare team determine how much scarring and fatty changes have occurred in the liver. The risk of cardiovascular disease should be assessed using a validated tool. The NAFLD fibrosis score calculator identifies liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). Feb 3, 2025 · Fatty liver on imaging Alcohol Use in NAFLD Chronic alcohol use can contribute to liver fat accumulation and fibrosis progression in patients with risk factors for NAFLD. There is no known safe level of alcohol use for patients with NAFLD/NASH. These include FibroTest-ActiTest, a first-line screening assay that uses two diagnostic scores based on component tests for six biomarkers to assess the liver for nonalcoholic fatty liver disease (NAFLD); nonalcoholic steatohepatitis (NASH)-FibroTest, which evaluates 10 biomarkers to assess liver condition; and direct alcohol biomarker testing We would like to show you a description here but the site won’t allow us. For instance, extremely elevated Body Mass Index (BMI) can impact the reliability of the score. The FIB-4 panel is also offered as the FIB-4 Index Panel With Reflex to Enhanced Liver Fibrosis (ELF) Score (test code 12734), with reflex testing performed at an additional charge with an additional CPT code. Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), through to advanced fibrosis and cirrhosis. It is important to be able to assess the severity of the disease process; in particular, it is essential to be able to assess the amount of fibrosis present, as this is the best predictor of Dec 17, 2023 · 2. Mar 22, 2023 · The most common cause of liver fibrosis is nonalcoholic fatty liver disease (NAFLD), while the second is alcoholic liver disease due to long-term excesses of drinking alcohol. Methods: We prospectively included participants from the general population, and people at risk of ALD or NAFLD. Management of NAFLD in primary care includes: Calculate NAFLD (Non-Alcoholic Fatty Liver Disease) Fibrosis Score to assess liver fibrosis risk. The nonalcoholic fatty liver disease fibrosis score (NFS) is comprised of unique metabolic risk indicators that may accurately predict residual cardiovascular (CV) risk in patients with established coronary disease and metabolic dysfunction. 2 days ago · Transient elastography with controlled attenuation parameter (CAP) simultaneously quantifies fat deposition and assesses fibrosis 4 Fibrosis Assessment Non-invasive fibrosis scores (FIB-4, NAFLD fibrosis score) are essential for risk stratification, as they identify patients at risk for advanced fibrosis who require hepatology referral 4, 6, 5 We aimed to validate the available indexes in NAFLD subjects and to test their ability to predict liver damage also in comparison with the NAFLD fibrosis score. It uses ultrasound technology to measure the “stiffness” of the liver. Scores based on laboratory values and demographic variables have been developed and validated for assessing fibrosis in patients with hepatitis C virus (HCV) infection and nonalcoholic fatty liver disease (NAFLD), as have several imaging methods that measure shear-wave Dec 15, 2019 · Common serum and ultrasound-based screening tests to assess fibrosis include the aspartate transaminase to platelet ratio index score, Fibrosis 4 score, FibroTest/FibroSure, nonalcoholic fatty FibroScan (TE) in Hepatitis C When the elastography and FibroTest (e. FibroScan can be used Thus, intensive research has been performed to develop noninvasive methods for the diagnosis of nonalcoholic steatohepatitis (NASH) | Non-Alcoholic Fatty Liver Disease, Fibrosis and Fatty Liver We would like to show you a description here but the site won’t allow us. Identify Hepatitis We compared the performance of the enhanced liver fibrosis (ELF) test to the fibrosis-4 index (FIB-4) and NAFLD fibrosis score (NFS), using transient elastography as the reference standard. We aimed to assess the utility of a pragmatic approach to screening for clinically significant fibrosis in primary care and Mar 28, 2025 · The nonalcoholic fatty liver disease (NAFLD) fibrosis score is a less invasive alternative to a liver biopsy that can help predict your risk for liver damage. Jun 16, 2025 · How does my doctor determine if I have NAFLD or NASH? Because most people with NAFLD have no symptoms and screening for it is not recommended at this time, fatty liver disease is often discovered during a routine blood test or screening for another medical condition. Metabolic dysfunction–associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), [a] is a type of chronic liver disease. For the specific task of diagnosing early-stage fibrosis, serum biomarker panels, particularly the ELFTM test, demonstrate better utility, with scores showing a clearer correlation with the progression from no fibrosis to early and significant fibrosis. Bansal adds. The NAFLD (Non-Alcoholic Fatty Liver Disease) Fibrosis Score estimates amount of scarring in the liver based on several laboratory tests. Management of NAFLD in primary care includes: We would like to show you a description here but the site won’t allow us. : Fibro Sure, Fibro Test-ActiTest) results agreed, liver biopsy examination confirmed the stage of fibrosis in: 84 percent of cases for F ≥2 fibrosis, 95 percent for F ≥3 fibrosis, and 94 percent for F = 4 fibrosis Whilst it is clear that NAFLD is common within the general population, this generally causes little in the way of morbidity or mortality. LifeLabs® offers the Fibrosis-4 (FIB-4) Index and Enhanced Liver Fibrosis (ELF™) Score to screen for liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). The FibroSure® test is an algorithm-based test that provides scores for fibrosis, steatosis and NASH based on the results obtained for several blood markers. It is not a comprehensive pathway for the investigation of abnormal LFTs. Primary risk assessment of patients with fatty liver disease You should start with a serologic test (e. Jan 12, 2025 · The Fatty Liver Fibrosis Score Calculator provides general health information for educational purposes only. Many patients with NAFLD remain undiagnosed and recognizing those Mar 15, 2024 · Unfortunately, NAFLD is diagnosed by exclusion, and the gold standard for identifying NAFLD/NASH and reliably measuring liver fibrosis remains liver biopsy, which is an invasive, costly, time-consuming procedure and involves variable inter-observer diagnosis. The Enhanced Liver Fibrosis (ELF) Score is a noninvasive test that indicates whether a patient with NASH and advanced fibrosis has a higher or lower risk of disease progression to cirrhosis (for those with F3 fibrosis) or other liver-related clinical events (for those with F3 or F4 fibrosis) within 1 to 4 years. Identify Hepatitis In some patients, this fat accumulation is accompanied by varying degrees of inflammation and fibrosis (nonalcoholic steatohepatitis [NASH]). 1 It’s a condition characterized by the presence of hepatic steatosis, typically associated with type 2 diabetes mellitus and obesity. 5 days ago · Across studies, AI models consistently outperformed non-invasive scores such as Fibrosis-4 Index (FIB-4) and NAFLD Fibrosis Score (NFS) and showed superior accuracy to standard clinical scores. We We would like to show you a description here but the site won’t allow us. Aims To describe the distribution of the biomarker scores Fibrosis‐4 (FIB4), nonalcoholic fatty liver disease (NAFLD) fibrosis score (NFS), and aspartate aminotransferase to platelet ratio index Liver fibrosis scores, including the NAFLD fibrosis score (NFS), Fibrosis-4 index (FIB-4), and Forns score, were used to assess the degree of liver fibrosis and, by extension, to reflect the severity of MASLD. An ideal risk score will be easy to use, cheap, and accurate. FibroScan What it measures: fibrosis, steatosis Who should take it: undiagnosed and diagnosed NAFLD/NASH patients Where to get it: specialty care centers, hospitals, some primary care providers FibroScan is an imaging-based diagnostic test developed by Echosens that looks at liver fibrosis (stiffness, scarring) and steatosis (fat) using transient-elastography technology. Jul 10, 2025 · What is the NAFLD Fibrosis Score? The NAFLD Fibrosis Score (NFS) is a widely used and validated clinical scoring system designed to identify patients with non-alcoholic fatty liver disease (NAFLD) who are at high risk for advanced liver fibrosis (stages F3-F4). These non-invasive blood tests help identify high-risk patients and reduce the need for complex procedures, ensuring early and effective management of liver health. Noninvasive serum biomarkers (nonalcoholic fatty liver disease fibrosis score [NFS], fibrosis 4 score [FIB-4], or enhanced liver fibrosis [ELF] test) are recommended as first-line tools to determine the risk of advanced fibrosis in nonalcoholic fatty liver disease. 2 If left undiagnosed, many patients with NAFLD progress to Nov 15, 2020 · There are two forms of NAFLD: nonalcoholic fatty liver (NAFL), defined as 5% or greater hepatic steatosis without hepatocellular injury or fibrosis, and nonalcoholic steatohepatitis (NASH The absence of steatosis (S<0. Apr 12, 2023 · Non-invasive tests that can accurately identify patients with at-risk NASH (ie, individuals with biopsy-proven NASH with NAFLD activity score [NAS] ≥4 and fibrosis stage ≥2) are key tools to identify candidates for pharmacologic therapy in registrational trials for the treatment of NASH-related fibrosis. 3 days ago · Simple blood test panels are commonly used to calculate risk scores, such as the Fibrosis-4 (FIB-4) index and the NAFLD Fibrosis Score (NFS). It can be defined as the liver manifestation of a metabolic disorder, and is the most severe form of non Jan 1, 2011 · Liver biopsy (LB) is the only means to evaluate fibrosis in NAFLD. NAFLD (Non-Alcoholic Fatty Liver Disease) Fibrosis Score The NAFLD Fibrosis score estimates the amount of scarring in the liver based on several laboratory tests. Healthcare professionals can use the FibroScan on its own or in combination Jul 27, 2025 · While the NAFLD Fibrosis Score is a useful screening tool, it functions as an indicator rather than a definitive diagnostic test. There are several risk scores out you may have heard about such as FIB-4 (Fibrosis-4), APRI (AST to platelet ratio index), and NFS (NAFLD fibrosis score). Dec 12, 2025 · This liver condition is becoming more common in the Western world. NAFLD can range from mild to severe. , FibroScan) and other blood-based tests, Dr. NAFLD Fibrosis Score - The NAFLD fibrosis score is a simple noninvasive approach to identify patients that may have significant liver fibrosis and who therefore might benefit from additional studies such as elastography or liver biopsy. Patients with NAFLD should be assessed for alcohol use and be encouraged to abstain from alcohol We would like to show you a description here but the site won’t allow us. Learn when it's used, how the score is calculated, and how to interpret results. Free online tool for medical professionals. Background/Objectives: Artificial intelligence (AI) is an emerging technology for diagnosing liver fibrosis in Metabolic-Dysfunction-Associated Steatotic Liver Disease (MASLD), but a comprehensive The secondary outcomes were ≥1-point improvement in the nonalcoholic fatty liver disease activity score (NAS), ≥1-point improvement in steatosis, ballooning degeneration, lobular inflammation scores, and fibrosis stage, improvements in NITs for fibrosis and steatosis, weight changes, and rates of serious adverse events (SAEs). 41) precludes the diagnosis of NASH, now known as metabolic dysfunction-associated steatohepatitis (MASH). This buildup of fat is not caused by heavy alcohol use. It will appear in the oval on the far right (highlighted in yellow). 455), suggests advanced liver fibrosis. NAFLD-FS Documentation Forms – Forms to use when documenting your use of NAFLD-FS with patients. 7–10 ELF is included as a The NAFLD fibrosis score is used to distinguish between patients with nonalcoholic fatty liver disease who have (F3-F4) and do not have (F0-F2) advanced fibrosis. Jan 7, 2026 · A score less than 1. Find out about non-alcoholic fatty liver disease (NAFLD), a common condition where fat builds up in the liver. NASH stands for Non-Alcoholic SteatoHepatitis. 3 or higher suggests you may want further liver assessment There are several follow-up tests available, including measurements of liver stiffness, such as liver elastography (e. Bansal explains. Aug 23, 2022 · Doctors use the NAFLD fibrosis score to predict how much scarring there is in the liver. The aim of the present study was to prospectively evaluate and compare the diagnostic accuracy of several blood fibrosis tests including ELF test and the simple tests, NFS and FIB-4, as well as VCTE for detection of fibrosis stage among patients with NAFLD with or without NASH. We compared the performance of the enhanced liver fibrosis (ELF) test to the fibrosis-4 index (FIB-4) and NAFLD fibrosis score (NFS), using transient elastography as the reference standard. Jan 9, 2026 · Moreover, LIGs were identified in human MASLD livers and exhibited reverse correlation with fibrosis progression. 1 mL serum collected in a serum separator tube (SST) and1 mL whole blood collected in an EDTA (lavender-top) tube Mar 28, 2025 · A FibroScan is an imaging test, so it doesn’t require blood work like the process used to assign an NAFLD fibrosis score. Use our NAFLD Fibrosis Score Calculator to assess liver fibrosis risk, improve monitoring, and support better overall liver health. 3 indicates a low risk for significant fibrosis A score of 1. Assess NAFLD fibrosis risk accurately with the NAFLD Fibrosis Score, a reliable tool for healthcare professionals. The risk of advanced liver fibrosis should be assessed using a non-invasive scoring system, such as the NAFLD Fibrosis Score (NFS), Fibrosis (FIB)-4 score or the Enhanced Liver Fibrosis (ELF) test. Non-alcoholic fatty liver disease (NAFLD) affects approximately 30% of adults in developed countries. 67 suggests advanced liver fibrosis. 2 If left undiagnosed, many patients with NAFLD progress to We would like to show you a description here but the site won’t allow us. We would like to show you a description here but the site won’t allow us. Mar 1, 2019 · Staging of liver fibrosis is increasingly done using noninvasive methods, in some cases obviating the need for liver biopsy. The other diagnostic scores are the Enhanced Liver Fibrosis (ELF) blood test score, BARD score (B MI, A ST/ALT R atio, presence of D iabetes), and APRI (A ST to P latelet R atio I ndex). Surrogate indexes were validated by the tracer technique (6,6-D2 -glucose and U- (13) C-glucose) in the basal state and during an oral glucose tolerance test. , fibrosis-4 index or FIB-4) with a high negative predictive value (NPV) to exclude advanced fibrosis. This tool does not provide medical advice, diagnosis, or treatment. Two scoring systems, NAFLD fibrosis score and BARD score, were proposed to separate… We would like to show you a description here but the site won’t allow us. Using your liver stiffness result to find your fibrosis score Your healthcare provider will use your liver stiffness result and medical history to find out your fibrosis score. Keywords: NAFLD, liver fibrosis, liver biopsy, non-invasive assessment, liver stiffness Introduction Non-alcoholic fatty liver disease (NAFLD) refers to the presence of liver steatosis in the absence of factors that are known to induce lipid accumulation in hepatocytes, such as alcohol consumption or the use of steatogenic drugs. Normal: This means your liver has no scarring, or mild scarring. If the person is at high risk of advanced liver fibrosis, refer to a hepatology specialist for further assessment and management. Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, affecting at least a quarter of the global adult population. In patients with NAFLD, liver fibrosis is among the most important predictors of progression to end-stage liver disease and outcome. g. It relies on readily available clinical information and routinely measured laboratory data. These scores combine routine laboratory values, including liver enzymes and platelet counts, with patient age to estimate the likelihood of advanced fibrosis. Therefore, we identified a new granule in steatotic hepatocytes and elucidated its role in restraining liver fibrosis. Although several tools exist including the NAFLD Fibrosis Score (NFS) and the AST to Platelet Ratio Index, FIB-4 is the most well Recommendation 7: Adults with NAFLD should undergo risk stratification to deter-mine the extent of their liver fibrosis (figures 1 and 2). AIM: To study whether the severity of liver fibrosis estimated by the nonalcoholic fatty liver disease (NAFLD) fibrosis score can predict all-cause mortality, cardiac complications, and/or liver complications of patients with NAFLD over long-term follow-up. Given risks and limitations of biopsy, non-invasive tests such as NAFLD fibrosis score, aspartate transaminase Jan 7, 2026 · The test that can predict your risk of significant liver fibrosis When it comes to AST and ALT, there’s a simple score that can help assess your risk for liver fibrosis or advanced disease, Dr. First-line testing should use either fibrosis-4 (FIB-4) or NAFLD Fibrosis Score (NFS) – see table 3 (level 2b, grade B). Objective Liver biopsy is the most accurate method for determining stage and grade of injury in non-alcoholic fatty liver disease (NAFLD). However, if any of these markers are unusually high or low, the FibroSure® algorithm may not be able to calculate one or more of the scores accurately. Fibrosis (FIB)-4 Score (FIB-4) — a score of greater than 2. PLEASE NOTE: This pathway is a guide for the use of the ELF Score in the assessment of advanced liver fibrosis in patients with NAFLD. Aug 1, 2023 · There is a need for accurate biomarkers of fibrosis for population screening of alcohol-related and non-alcoholic fatty liver disease (ALD, NAFLD). Find out how to treat and prevent this potentially dangerous liver disease. Non-Alcoholic Fatty Liver Disease (NAFLD) & Non-Alcoholic Steatohepatitis (NASH) Nonalcoholic Fatty Liver Disease (NAFLD) is a condition in which excess fat builds up in your liver. Alcoholic liver disease (ALD), also called alcohol-related liver disease (ARLD), is a term that encompasses the liver manifestations of alcohol overconsumption, including fatty liver, alcoholic hepatitis, and chronic hepatitis with liver fibrosis or cirrhosis. Problems arise with the development of inflammation and fibrosis. It is closely linked with obesity as well as type 2 diabetes. The Enhanced Liver Fibrosis (ELF™) blood test is a simple, accurate, noninvasive test that provides a simple, unitless numeric score that is generated via an algorithm for use in advanced liver fibrosis. NAFLD Fibrosis Score (NFS) — an intermediate or high score (greater than minus 1. We aimed to assess the utility of a pragmatic approach to screening for clinically significant fibrosis in primary care and Jan 16, 2023 · The highest possible result is 75 kPa. Your results can range from normal to advanced. Its accuracy can be influenced by various factors, and it may not be as precise in all patient populations. Jul 6, 2016 · This guideline covers how to identify the adults, young people and children with non-alcoholic fatty liver disease (NAFLD) who have advanced liver fibrosis and are most at risk of further complications. NAFLD affects 25% of the population, making it the most common liver disease worldwide. The bottom line? Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease Journal of Hepatology, 2016 Enhanced Liver Fibrosis (ELF) Score - The Enhanced Liver Fibrosis (ELF) score predicts progression to cirrhosis and liver-related events in patients with advanced fibrosis due to NASH. Enter the required values to calculate the FIB-4 value. This NAFLD fibrosis score calculator stratifies the degree of fibrosis to the liver in nonalcoholic fatty liver disease patients by assigning a specific stage.